grand climacteric (noun) change of life: end of menstrual cycle
Sinonime: blow a gasket, blow one's mind, blow one's stack, blow one's top, crack up, flip one's lid, flip out, fly off the handle, freak out, go ballistic, go bananas, go batty, go berserk, go bonkers, go buggy, go cuckoo, go daffy, go haywire, go kooky, go loco, go loony, go mental, go nuts, go nutty, go off, go off one's rocker, go off the deep end, go off the wall, go psycho, go wacko, go wacky, lose control of oneself, lose it, lose one's cool, lose one's mind, wig out